Project on chronic
We examine how the disruption of cellular networks drive fibrotic diseases. We employ comprehensive, cutting-edge single-cell analyses of fibrotic organs to make novel mechanistic insights and develop therapeutic strategies for fibrosis.
Project on hepatitis B
HBV, a virus that is difficult to eliminate completely after infection, causes hepatitis B, which leads to 680,000 deaths annually around the world. We are currently investigating some small molecules that could potentially eliminate HBV from infected patients.
Project on anti-CD4
therapy against solid tumors
We have performed the phase I study for an anti-CD4 therapy against solid tumors in patients in 2018, based on this therapy’s robust anti-tumor effects in mice. We have determined novel combinations of anti-tumor immunotherapies and have elucidated their mechanisms.
Project on regulation
of chemokine signaling
We identified the novel chemokine receptor-coupled molecule “FROUNT” and are investigating how FROUNT regulates chemotaxis and inflammation. As a part of this project, we have developed some anti-cancer/inflammatory drugs which target FROUNT and its functioning.
Chronic GVHD is a major cause of death after allogenic hematopoietic stem cell/bone marrow transplantation. We are investigating the mechanisms of chronic GVHD-induced immune defects by using several murine GVHD models.